The registry fix is only to be used on a system when the drive is missing from My Computer and Device Manager.
I'd suggest to download the "cdgone.zip" file and use only it to perform the fix with. It can be used several times so don't be afraid to try it several times. Either the drive is faulty or you're missing some small detail as the fix is a tried and tested fix for over 6 years.
As a last resort you can always use the recovery method for your machine and get it back to the way it was when you bought it, however if you have important files or data on the machine, you'd need to do a backup first.
And here's some additional info:
Also, for optical drive problems in
Windows Vista, read
this HP web page. Even though it's for HP/Compaq machines, the same principal applies to all modern IDE optical drives regardless of brand.
If your drive stopped working after installing an Adobe product, please read
this thread. Note: about 2/3rds. down the page is a video that shows how to perform the "delete upper and lower filters fix".
This is a multi-page thread dealing with issues of the optical drive and problems encountered in Windows XP and Vista. It covers a lot of issues and the most common causes and solutions.
Click here to read the thread.
You can get instructions for performing this fix from Microsoft at
this page [Windows XP] and from
this page. [Windows 2000]